Essex County OPP says four people have been sent to hospital, and two of them have been arrested, after a collision on Highway 3 near Walker Road.
A Lexus and Volkswagen collided head-on around 9 a.m. Wednesday.
Police say the injuries are life threatening. People had to be extricated from two vehicles.
A police canine could be seen searching one of the vehicles involved in the crash with officers armed with rifles.
Sources tell CTV News police were searching the vehicles for guns, but the OPP would not comment on the investigation.
Police have not released information about the two people in custody.
Highway 3 was closed between Oldcastle Road and Sexton Sideroad for most of the day. It reopened around 4 p.m.