Essex County OPP are investigating a fatal crash on Highway 401 near Cabana Road.
OPP say the collision involved three tractor trailers and an SUV.
It happened about 4 p.m. in the westbound lanes of the highway in Tunnel 5, north of the Todd Lane overpass.
Police confirmed one person is deceased and no further details will be released until next of kin is notified.
Highway 401 at Exit 7 was closed for westbound traffic for an investigation for several hours with the lanes reopening around 1 a.m.
Four vehicles were involved in the crash.