Talbot Road was closed for several hours between LaPointe Street and Wilson Side Road in Lakeshore following a collision Tuesday evening.

Provincial police say the crash occurred just before 8 p.m. when a pickup truck and a Cadillac collided head-on.

The driver of the pickup was taken to hospital with life-threatening injuries while the Cadillac driver suffered non-life threatening injuries.

OPP Technical Traffic Collision Investigators were on scene late into the night to try and determine the cause of the collision.

The roadway has since reopened.