A man was airlifted to a London hospital after an overnight fire in Windsor's east end.

Police have one person custody after the fire destroyed a garage early Monday morning at 1515 Arthur Rd.

"It was completely engulfed in flames like a giant fire ball that went up in the sky," said witness Mark Radigan.

Another witness Craig St. Pierre saw the man burned.

"You could tell he was injured, how he was walking. He looked like a man that was burnt bad, so you knew he was seriously injured."

Crews were called to the scene about 2:30 a.m.

Officials say the victim taken to hospital has burns to 35 per cent of his body - on his neck, hands and legs.

The Fire Marshal's Office is investigating the blaze.

Damage is estimated at $100,000.